Agranulocytosis and Severe Leucopenia after Chlorpromazine

Severe Agranulocytosis following Simultaneous Administration of Chlorpromazine and Trimethoprim-Sulfamethoxazole in a Patient with Sepsis: A Possible Toxic Combination

Background. Chlorpromazine and trimethoprim-sulfamethoxazole (TMP/SMX) are two commonly prescribed medications by physicians. Either of those medications could cause fatal drug-induced agranulocytosis, with an unclear underlying mechanism. The likelihood of simultaneous prescription of both medications is high and could hypothetically result in severe agranulocytosis that is resistant to treatm...

Severe and prolonged febrile agranulocytosis under thyrosol

Background It is well known that patients with severe neutropenia are susceptible to bacterial infections, which may become lifethreatening. This hematologic disorder frequently occurs as an adverse effect of certain drug therapies. One of them, currently encountered in practice, is therapy with antithyroid drugs. An infective source is identified in average in 20-30% of febrile neutropenia epi...

A drug-specific leuco-agglutinin in a fatal case of agranulocytosis due to chlorpromazine.

A fatal case of agranulocytosis due to chlorpromazine is reported. Mechanisms other than immunological are generally believed to be responsible for chlorpromazine-induced agranulocytosis. However, the demonstration of a drug-specific leuco-agglutinin in the serum of this patient suggests that an immunological mechanism was responsible for the agranulocytosis.

First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.

Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role fo...

Severe Mucor necrotizing fasciitis associated to dipyrone-induced agranulocytosis.